A REVIEW ON POLYMERIC MICELLES: IN VITRO CELL LINE STUDY AGAINST DIFFERENT CANCER CELL LINES

Abstract

Polymeric micelles have been the subject of many studies in the field of drug delivery. The interest has specifically been focused on the potential application of polymeric micelles in three major areas in drug delivery: drug solubilisation, controlled drug release and drug targeting. Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer drugs. The present article is focusing the in vitro cell line study of different drug loaded polymeric micelles of various anticancer drug like ursolic acid, methotrexate, curcumin, doxorubicin and paclitaxel by various in vitro cytotoxic assay like MTT and CCK-8 against different cancer cell lines like HepG2, L-02, CT26, HT-29, Caco-2, MCF-7 and A549. Cell culture model are adequate for screening toxicity of several substances including polymeric micelles and the assays help to determine whether any of the anticancer drug loaded polymeric micelles has toxicity or proliferative activity. The data from those models can provide an indication of safety use of these particles in humans.