EVALUATION OF VITAMIN D LEVELS AND THYROID PROFILES TO DETERMINE THE LEVEL OF FEMALE INFERTILITY WITHOUT ANY SYSTEMIC DISEASE

Abstract

Background: Vitamin D receptors are found in the majority of human tissues and cells; vitamin D has historically been regarded as a special hormone which can reduce the chance of developing chronic disease. Thyroid hormone primarily controls metabolism, growth, and many other bodily functions.

Aim: In order to examine female infertility, the thyroid profile and blood vitamin D levels were measured in the current investigation.

Methods: The history of the subject who was unable to conceive after a year of regular sexual activity in subjects without accompanying systemic disorders such as diabetes, hypertension, or cardiovascular diseases was used to make the diagnosis of infertility. Thyroid and vitamin D profiles were measured in 96 fertile controls and 48 infertile females in the research.

Results: The values of vitamin D were shown to be 13.7±7.67, whereas the controls had considerably higher levels (20.7±6.45) (p<0.01). Regarding vitamin D insufficiency, it was observed that 32.29% (n=31) of the controls and 20.83% (n=10) of the patients reported having a slight deficit. 22.91% (n=11) cases and 2.08% (n=2) controls had severe instances, while 33.33% (n=16) cases and 7.29% (n=7) controls had intermediate cases. About the thyroid profile of the fertile and infertile females, it was observed that the TSH level was significantly higher in the cases (6.42±1.04) with p<0.01, T4 levels were significantly higher in the controls (6.41±2.06) than in the cases (5.2±3.54), and T3 levels were significantly higher in the controls (0.93±0.26) than in the cases (0.72±0.55) with p<0.01. Among the research participants, euthyroidism, hypothyroidism, and hyperthyroidism were seen in 41.66% (n = 20), 8.33% (n = 4), and 50% (n = 24).

Conclusion: The current study comes to the conclusion that there is a negative link between vitamin D and TSH levels and female infertility. But further analysis is required on this. Thyroid profile and vitamin D levels should be routinely checked on all female women with infertility.