STUDY ON IRON PROFILE PARAMETERS AND SEVERITY OF COPD AS PER GOLD CRITERIA AT OUR TERTIARY CARE HOSPITAL

Abstract

Background: The prevalence of COPD in the young Indian population aged 30 is 7%. The most common cause of COPD is tobacco smoke, and the other factors that can cause or make COPD worse are environmental exposures and genetic risk metabolism is altered by inflammation. The iron level in plasma will decrease, with the transferrin.

Aim: To estimate Iron Profile parameters in stable And AECOPD patients. To correlate the iron profile parameters according to severity of COPD using GOLD criteria (2021).

Methods: A total number of 302 patients were included in the study. This includes 151 stable COPD patients and 90 AECOPD patients of the age group of 30 to 60 years of age group. Venous blood was drawn from patients for iron profile parameters in a plain vial and performed the test at the Central Biochemistry laboratory at the National Institute of Medical Sciences and Hospital (NIMS Hospital) where serum iron, ferritin, Total iron binding capacity (TIBC), and Transferrin saturation (TS%) were measured. Student’s t-test was used for the comparison of iron profile parameters.

Results: There is a significant decrease in the level of serum iron and TS% in acute exacerbation (AE) COPD as compared to stable COPD patients (p < 0.001). There is a significant increase in the level of serum ferritin and TIBC in acute exacerbation (AE) COPD as compared to stable COPD patients (p < 0.001).There is no significant difference in iron profile parameters with the severity of the disease (p>0.05).

Conclusion: The present study highlights the low level of serum iron and TS% and high level of serum ferritin and TIBC in acute exacerbation (AE) COPD patients as compared to stable COPD patients. The study did not find a statistically significant correlation between the iron profile parameters and the severity of COPD.