FORMULATION AND EVALUATION OF HYDRODYNAMICALLY BALANCED FLOATING TABLETS OF GLYCYRRHIZA GLABRA EXTRACT

Abstract

The aim of the study is to formulate, optimize and evaluate Glycyrrhiza glabra floating tablets using 23 optimization technique for the treatment of
asthma. The extract of Glycyrrhiza glabra was prepared by subjecting crude drug to hot continuous percolation method using Soxhlet apparatus using
distilled water and ethanol. The floating matrix tablets of Glycyrrhiza glabra was prepared by wet granulation technique using extract of Glycyrrhiza
glabra, HPMC K15M as polymer, starch/honey as binder and sodium bicarbonate & citric acid as effervescent agents by 23
factorial design. The
independent variables are polymer (X1), concentrations of effervescence agents (X2) and binders used for granulation (X3). The dependent variables
are hardness (Y1), buoyancy lag time (Y2), total floating time (Y3), and in-vitro drug release (Y4). The compatibility studies showed that there is no
chemical interaction between the drug, polymer and the excipients used in the tablets. The prepared floating tablets were subjected to all post
compression parameters such as hardness, friability, swelling capacity, buoyancy, total floating time, drug content &in-vitro drug release and were
found to be within normal limits. Based on drug content, buoyancy lag time and in-vitro drug release the formulations F8 was found to be the promising
system for anti-asthmatic therapy. The present study reports for the development of gastric floating tablet for Glycyrrhiza glabra following oral
administration.