VALIDATION OF SCREENING MODEL OF ANTI PSYCHOTIC DRUG: A REVIEW
Keywords:
validation, screening models, anti-psychosis, In-silico models, animal modelsAbstract
Psychosis is a generalized term which used to describe the abnormal mental state. It is a common and functionally disruptive symptom of a variety of
psychiatric, neurodevelopmental, neurologic, and medical conditions, as well as an important target for diagnosis and treatment in neurologic and
psychiatric practice. Therefore, to treat the psychosis condition anti-psychotic medications are deployed these drugs in general work on different
receptors of brain like the dopamine receptor to ease the psychotic conditions. Since these drugs work directly on the brain receptors the validation of
screening models of anti-psychotic drug become really important and for that in broadly two ways are mainly approached i.e, the In-silico study where
docking is deployed and the animal models’ utilizations to study the effectiveness and toxic effect of drugs. Hence, in this article brief history of
psychosis is discussed along with the approaches that validated the screening model of anti-psychotic drugs.
