EVALUATION OF LOCOMOTOR AND DIURETIC ACTIVITIES OF AQUEOUS AND ALCOHOLIC EXTRACTS OF LEAVES OF EPIPREMNUM AUREUM L.
Keywords:
Epipremnum aureum,, Locomotor activity, Diuretic activity,, Actophotometer, Lipschitz test.Abstract
The aim of the present study was to evaluate the locomotor and diuretic activities of both aqueous and alcoholic extracts of leaves of Epipremnum aureum (AQEEa and ALEEa) in experimental animals. Locomotor activity was evaluated by actophotometer and diuretic activity was evaluated using Lipschitz test model in rats. Preliminary phytochemical screening showed the presence of alkaloids, flavonoids, terpenoids and saponins. Intra peritoneal administration of AQEEa and ALEEa at doses 200mg/kg produced significant (P< 0.01) CNS depression by reducing locomotor activity while it showed a significant (P< 0.01) increase in the urine volume when compared to control. Thus, in conclusion the AQEEa and ALEEa have a significant CNS depression action by reducing locomotor and diuretic action in rats.
