A WAY TO INCREASE EFFECTIVENESS OF PARACETAMOL DRUG THROUGH TRANSDERMAL PATCH

Abstract

Millions of people around the world suffers from the fever, effective treatment is essential by formulating Transdermal patch. Paracetamol IP traditionally considered as a NSAID, is an effective analgesic and antipyretic fully sold without prescription. The conventional formulations containing high dose as well as required to take the medication frequently so increase the risk factor associated with drug. The present study is an attempt to develop suitable matrix type patch of Paracetamol using blends of Xanthan Gum and HPMC K4M with polyethylene glycol (PEG-400) as a plasticizer. To get better effect permeation enhancers such as Linseed oil and oleic acid was also incorporated and their optimum concentration was determined. Prepared formulations were evaluated for compatibility, drug content, moisture loss and absorption, thickness, weight variation, adhesion, folding endurance etc. In vitro permeation study was performed by using Franz diffusion cell. Formulations were found to be uniform in physicochemical parameter with a fewer variations and there was no significant interaction between drug and polymer used. Formulation of HPMC K4M along with Linseed oil showed faster release of drug from developed formulations. Based on the observation, No burst effect but HPMC K4M are better for faster release with linseed oil and xanthan gum for prolonged release for the development of patch. Stability studies indicated the formulations were remained stable both physically and chemically. All developed formulations showed desired properties of an ideal TDDS and followed zero order rate profile. Thus, the study achieved targets by reduction in frequency of administration and systemic toxicity.