SYNTHESIS AND STUDY OF 3-METHYL-N-[ARYLYLMETHYLENE]-1H-INDAZOL-5-AMINES FROM 2-HYDROXY-4-AMINO ACETOPHENONE AND THEIR ANTI-MICROBIAL ACTIVITY

Abstract

Indazole is one of the most important scaffolds in heterocyclic chemistry and drug design and discovery. It is rarely found in nature but widely found in diverse pharmacologically active substances. Indazoles are versatile building-block for lead generation, the indazole core is an active pharmacophore and used in medicinal chemistry and drug discovery research. A number of drugs with indazole core are in the market, In the recent years, many indazole derivatives have been synthesized and subjected to varied biological activities. Here indazoles are prepared from 2-hydroxy-4-amino acetophenone, the free amino group is preprotected and reacted with hydrazine hydrate at elevated temperature thus obtained indazoles are deprotected and hydrazone derivatives were prepared, the newly synthesized indazole derivatives were screened for antibacterial and antifungal activity.