ADVANCE TECHNIQUES OF CO-CRYSTALLIZATION - A REVIEW

Abstract

The two fundamental obstacles in developing novel products are poor water solubility and limited oral bioavailability. BCS classes II
(Low solubility/High permeability) and IV (Low solubility/Low permeability) account for 60-70 percent of newly invented drugs.
However, solubility and percentage of drug release are critical in determining drug molecules effectiveness. Several strategies are
established to improve the solubility of poorly soluble pharmaceuticals, but their effectiveness relies on the drug’s physical and chemical
qualities. Cocrystallization techniques are one of the greatest approaches to addressing and enhancing the solubility of poorly soluble
drugs. These are the multicomponent systems in which at least one component is a drug and others are carrier & pharmaceutical
acceptable ingredients. It also significantly improves physicochemical attributes like solubility, permeability, stability, and bioavailability
while preserving the pharmacological quality of active pharmaceuticals. This review presents an overview of pharmaceutical cocrystal
classification, highlighting several advantages and applications of Pharmaceutical cocrystal, numerous cocrystal manufacturing procedures,
and regulatory aspects. Additionally, analytical methods are discussed in this review for identifying cocrystals. This review will suggest
a more productive design and production of pharmaceutical cocrystals with ideal physical and chemical properties and applications.