A REVIEW ON MIXED HYDROTROPY: SOLUBILITY ENHANCEMENT TECHNIQUE FOR POORLY AQUEOUS SOLUBLE DRUGS

Abstract

In case of oral administration, solubility is a key factor to demonstrate the pharmacological response in achieving the desired bioavailability of drugs. But most of the time, due to dissolution as the rate-limiting step intended for absorption of poorly aqueous soluble drugs (BCS Class-II and IV), it becomes challenging to formulate conventional dosage forms of such drugs. Different perspectives have been extensively inspected to improve the aqueous solubility and poor dissolution rate of BCS Class-II and Class-IV drugs such as micronisation, self-emulsification, pH-changing solubilization, salt formation, co-solvent, solid dispersion and hydrotropic use etc. This analysis summarizes the use of hydrotropy, which is one of the promising practice for boosting solubility in several folds by adding surplus quantity of Hydrophilic solute to improve the aqueous solubility of the primary solute without any chemical alteration of the drug compound e.g. Urea, Niacinamide , Sodium salicylate, Sodium Citrate, etc. It has several advantages like it does not need organic solvent or establishment of the emulsion system.