DEVELOPMENT OF DUTASTERIDE LOADED MOUTH DISSOLVING TABLET AND USING DIRECT COMPRESSION METHOD

Abstract

This study aimed to create dutasteride mouth dissolve tablets using the direct compression technique and
superdisintegrant addition. Superdisintegrant addition technique was chosen for future research because it had the
lowest disintegration time out of the nine formulations when hardness and friability were taken into consideration. Nine
further batches (F1-F9) were produced utilizing SSG, crospovidone, and croscarmellose sodium in varying quantities.
Weight variation, hardness, friability, drug content, and the best formulation for mouth-dispersing tablets were all
assessed for each formulation. The pure dosage calibration curve was generated by dissolving the drug into ethanol &
measuring its absorbance with a UV spectrophotometer calibrated to 241.5 nm. The R2 score was 0.999.The size of
dutasteride particle predictions was done using light microscopy. The particles were 2.1 µm in size. All the prepared
formulations were undergone for their characterization. The optimized formulation showed that 99% of the medicament
was released in 4 minutes. However, its wetting time and disintegration time are 26 and 30 sec, respectively