RATIONALE OF DEPRESSION AND PURPOSE OF ANTIDEPRESSANT DRUGS: A REVIEW

Abstract

There is very vast empirical work that directly assesses the neurobiological association of neurochemicals and biochemical super factors with the liability to depression. Therefore, as a means of providing a framework for future research, this article outline the path physiology arises a consequence of altered regulation of particular brain chemicals. In addition, the present article reviews the evidence from both clinical and experimental studies which implicates rationale of depression and the mechanism from which antidepressant drug act for the maintenance of depressive illness. Present studies evolving rationale of the pathophysiology, catecholamine, Sleep alterations, Glucocorticoids, the Neurotrophic, Hypothyroidism, Emotionality and altered activity in depression and treatment of depression involves adaptation of neural systems. This rationale was based on a correlation of the psychological and cellular actions of a variety of psychotropic agents. This will be used as experimental tools to study pharmacological action of antidepressant drug.