ANTIBIOTIC UTILIZATION STUDY IN PATIENTS WITH NOSOCOMIAL PNEUMONIA IN A PEDIATRIC HOSPITAL IN PACHUCA, HIDALGO

Abstract

Objective of the study was to identify the antibiotics most frequently used for treatment of nosocomial pneumonia in the DIF Pediatric Hospital of Hidalgo and evaluate the rationality of their prescription by determining the intrinsic value of each antibiotic. This was a descriptive, cross-sectional, indication-prescription study that included patients hospitalized with nosocomial pneumonia from January to December 2014. Data were obtained using the electronic medical record program Histoclin® and were analyzed with SPSS v18. Seventy-six patients stratified by age group were studied with infants predominating in 47.4% of cases. The most frequently used antibiotics were beta-lactams 98.7%, glycopeptides 71%, aminoglycosides 35.5%, imidazole derivatives 32.9% and lincosamides 22.4%. Antibiotic treatment interruption at 48–72 hours was 12% (meropenem, cefepime and vancomycin). Intrinsic value according to blood cultures was correct in 100% of cases. Total consumption of antibiotics expressed as DDD/100 bed- days was for imipenem 9.23 DDD/100 bed-days, amphotericin B 9 DDD/100 bed-days, cefepime 8.27 DDD/100 bed-days, and vancomycin 8.11 DDD/100 bed-days. Total consumption of antibiotics during this period was 2,740,019.85 mg with a total investment of $2,724, 224.30 pesos. The intrinsic value of the evaluated drugs was correct. We recommend a standardized antibiotic administration guideline that favors their rational use.