FORMULATION AND EVALUATION OF ORODISPERSIBLE ROSUVASTATIN TABLETS: A COMPARATIVE STUDY ON NATURAL AND SYNTHETIC SUPER DISINTEGRENTS

Abstract

The delivery of drugs to the oral cavity, for local action or, in some cases, absorption across the oral mucosa, thereby avoiding first-pass hepatic metabolism and potentially increasing the rate and extent of uptake, and reducing undesirable metabolites these ODT’s plays a predominant role. The objectives of the research work was to formulate Rosuvastatin oral disintegrating tablet by using natural and synthetic superdisintegrents. in different ratio by direct compression technique and tablets were evaluated for precompressional and postcompressional Parameters such as angle of repose, bulk density, tapped density, compressability index, drug content and in-vitro drug release study, hardness, friability, wetting time and invitro dispersion time. To study the physical characteristics of the individual drug and optimized formulations by FTIR spectroscopy. To evaluate various characteristics of the resulting tablets. Formulation F3 was shown good releasing characteristics when compared all the super disintegrents.