SYNTHESIS AND EVALUATION OF IODINATED PHENYTOIN FOR ANTIMICROBIAL ACTIVITY
Keywords:
Phenytoin (5,5-diphenyl imidazolidin-2,4-dione), 5,5-bis(4'-iodophenyl)imidazolidine-2,4-dione, N-3-acetylcarboxy-5,5-bis(4'- iodophenyl)imidazolidine-2,4-dione, antibacterial activityAbstract
5,5-bis(4'-iodophenyl)imidazolidine-2,4-dione was prepared either by direct iodination of 5,5-diphenyl imidazolidin-2,4-dione (phenytoin) or through the iodination of phenytoin intermediates (benzoin and benzil) and follow-up the standard procedure used for conversion of them to phenytoin. The targeted compound was evaluated and compared with the antimicrobial activity of phenytoin.
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Published
11-03-2014
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