ANTIBACTERIAL, ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITIES OF THE HYDROALCOHOLIC EXTRACT OF THE LEBANESE ANNONA SQUAMOSA L. SEEDS

Abstract

To determine the chemical composition of the seeds of the Lebanese Annona squamosa L., a phytochemical screening was performed on a water/methanol (v/v) extract. Following that, several quantitative tests were carried out to determine the content of the seeds in the secondary metabolites. Also, the nutritive and medical importance was evaluated in order to realize some biological activities such as antibacterial, antioxidant and anti-proliferative activities. The obtained results showed that the hydroalcoholic extract from the seeds of this fruit contains a variety of primary and secondary metabolites like alkaloids, resins, saponin, phenols, terpenoids, flavonoids, carbohydrates and quinones. In addition, it has a low antioxidant activity and a bacteriostatic activity that is greater than a bactericidal agent. Finally, the seeds’ extract presented an anti-proliferative activity that is more effective on HCT-116 colon cells than on HT-29 epithelial cells. Further research studies need to be conducted to confirm the antibacterial, antioxidant and anti-proliferative effects of the seeds found in this fruit.