NOVEL FUSED 1H- IMIDAZO[1,2-B] PYRAZOLE ANALOGUES AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS WITH THEIR MOLECULAR DOCKING STUDIES AGAINST COX-1 AND COX-2

Abstract

New series of 2,6-disubstituted-1H-imidazo [1,2-b] pyrazole analogues were synthesized structures of these compounds were predicted and confirmed by IR, 1HNMR, 13CNMR, Mass spectral and elemental analysis. The newly synthesised compounds were evaluated for their acute toxicity, anti- inflammatory, analgesic activities properties and in-silico molecular docking studies synthesized compounds were exhibited significant anti- inflammatory and analgesic properties. The results indicated that had good affinity to the active site residue of COX-2 and COX-1 respectively. This strongly evidences that 2,6-disubstituted-1H-imidazo [1,2-b] pyrazole analogues are anti-inflammatory and analgesic agents which was supported by both in-vivo and in-silico studies.