SCREENING ANXIOLYTIC ACTIVITIES OF METHANOLIC FRUIT EXTRACTS OF SPONDIA PINNATA PLANT

Abstract

This Present study was surpassed to investigate the methanolic extracts of Spondias pinnata fruit for anxiolytical activities. S. pinnata is a plant of Anacardiacea family. The methanolic crude extract were screened for anxiolytic activities using hole board test method (***p < 0.001) and elevated- plus maze test method (***p < 0.001) in mice. Test results found 40.25±2.98 times for 400mg/ml extract in hole-board and 152.5±44.78, 147.5±, 9.25±1.79 times in elevated plus maze respectively as comparison with standard. The use of crude extracts of fruits of Spondias pinnata as anxiolytics have been confirmed that the fruits extracts displayed potential anxiolytic activity against mice for head dipping and stay in open and enclosed arms in the study. Various concentrations of extracts were tested and results were expressed in terms of time. In conclusion, the methanol extract of the fruits and plant of Spondias pinnata displayed anxiolytic activity.