DRUG CHARACTERIZATION STUDY OF ARIPIPRAZOLE FOR FORMULATION AND DEVELOPMENT OF NEWER ANTIPSYCHOTIC FORMULATION

Abstract

Aripiprazole is an antipsychotic medication, works by changing the actions of chemicals in the brain. It is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression). In order to formulate a newer aripiprazole immediate release of strength 30mg we performed the drug characterization study for the active pharmaceutical ingredient. Morphological characteristics, melting point, angle of repose, bulk density, tapped density, carr’s index, hausner ratio, sieve analysis, water content and moisture pick up were determined. The results obtained were satisfactory and within the specified limits. The drug characterization study was found to be useful for formulation and development of aripiprazole immediate release tablet.