SYNTHESIS OF SOME NOVEL 5- IMIDAZOLONES AND ITS ANTIMICROBIAL ACTIVITY

Abstract

Based on the importance of heterocyclic rings in the field of medicinal chemistry, a new series of 4-arylidene-1-((6-methyl-2-(p-tolyloxy)quinolin-3- yl)methyleneamino)-2-phenyl-1H-imidazol-5(4H)-one (3a-e) was designed, synthesized and screened for antimicrobial activity. In present investigation, 5-imidazolones (3a-e) have been synthesized by the condensation of 1-((6-methyl-2-(p-tolyloxy)quinolin-3-yl)methylene)hydrazine (1) with different 4-arylidene-2-phenyloxazol-5(4H)-ones (2a-e), in presence of dry pyridine as the solvent. Structure elucidation of the synthesized compounds was made on the basis of elemental analysis and spectral techniques such as IR, ¹HNMR, and further supported by Mass spectra. The title compounds were screened in-vitro for antibacterial and antifungal activity against different strains of bacteria and fungi. The result revealed that some of the title compounds exhibited significant antibacterial activity but were found to be inactive against the selected fungi.