SYNTHESIS AND CHARACTERIZATION OF COUMARIN ANALOGS: EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES

Abstract

Coumarins and their analogs were found to be better antitumoral agents and still active against human retroviral invading system. This property could be ameliorated by coupling of few active groups to the parental molecule for enhancing its frequency of biofunctional diversity and multi spectrum characteristic, such an endeavor was done by 2-Oxo-2H-chromene-3-carboxylic acid phenylamide analogs. The structure were well characterized. Further the antimicrobial activity was examined by disc diffusion method and based on the minimum inhibitory concentration (MIC) values obtained the molecules were approximately 70% as active as the positive control especially halogenated compounds showed promising result. Even their free radical scavenging activity was considerably as good as 20% to that of ascorbic acid. Present research on coumarin analogs necessitate novel ideas in synthetic chemistry therein concerning the development of innovative synthetic strategies that could help in drug design.