STUDY AND EVALUATION OF ANTIDEPRESSANT LIKE PROPERTY OF ETHANOLIC SEED EXTRACT OF ELAEOCARPUS GANITRUS IN ANIMAL MODEL OF DEPRESSION

Abstract

Depression is a widespread psychiatric disorder affecting around 5% population of the world. It is fourth leading cause of disease trouble universal by
ranked and it is expected to turn into the second most immobilizing disorder. Moreover, it is not easy to expect which patient will retort to whichever
given treatment. At present obtainable antidepressant drugs are effective and harmless, but limitations range from a delayed start of action to a
considerable rate of non-responders. In the systems of traditional medicine, numerous plants and formulations have been used to take care of
depression for thousands of years. We have reported antidepressant activity of EG. Therefore, the present study was start to evaluate the
antidepressant potential of fruit extract of Elaeocarpus ganitrus and fraction of Elaeocarpus ganitrus in forced swim test (FST) and tail suspension
test (TST). The mice were divided into six groups, each group containing five animals. Test drug Elaeocarpus ganitrus (EG) were suspended in
distilled water. The vehicle (10ml/kg, p.o), Imipramine HCl (10mg/kg, p.o), EGE and EGF (50mg/kg, 100mg/kg, 150mg/kg and 200mg/kg, p.o.
respectively) were administered 1 hour prior to study. Duration of immobility was noted in both the models. In our study, Imipramine HCl, EGE and
EGF significantly reduced the duration of immobility in both experimental models as compared to the animals in the control group. The
antidepressant activity of EGE and EGF were comparable to that of standard drug Imipramine HCl. The results of the present study indicate the
potential for use of EG as an adjuvant in the treatment of depression.