EVALUATION OF PHYTOCHEMICAL AND ANTI-MITOTIC POTENTIAL OF POLY-HERBAL EXTRACT BY USING ONION ROOT MODEL

Abstract

Cancer is one of the main causes of mortality around the globe. Majority of the plants are believed to have anticancer properties. The present review
was done to assess the antitumor action of various plants in combination, which was an attempt to prove the poly-herbal combination for in-vitro
anticancer property. In present study, different plant extracts such as Withania somnifera, Asparagus gonoclados, Azadirachta indica and Streblus
asper were used to prepare the combined extract which helps to determine cytotoxicity.
Anti-mitotic assay by onion root tip method was selected due to comprehensive results. Phytochemical investigation was carried out by standard
procedures for investigation of phytoconstituents. Significant reduction in mitotic index was observed in Poly-herbal extract in high concentration in
comparison to standard Vincristine as well as in comparison to individual plant extract with P value < 0.01.