PHARMACOLOGICAL POTENTIAL OF ERIOBOTRYA JAPONICA – AN OVERVIEW

Abstract

Pyrogenic contamination is a recurrent and troublesome problem in the preparation of solutions for parenteral use. Pyrogens, a chemically heterogeneous group of fever inducing compounds which are derived from bacteria, viruses, fungi or even from the host. Consequently, to assure the quality and safety of any pharmaceutical product for parenteral application in humans, pyrogen testing is mandatory. Endotoxins are the major contaminants which contribute to the pyrogenic response and complicate the interpretation of experiments using in vivo or in vitro biological responses. This review explains the different methodologies which are use to reduce pyrogens.