SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTIMICROBIAL EVALUATION OF INDOLINE BASED DERIVATIVES

Abstract

New series of indoline carbothioamide based derivatives have been synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and LCESI. All the synthesized compounds were screened for their antibacterial activity against four different strains specifically Staphylococcus aureus,
Bacillus subtilis Escherichia coli and Klebsiella pneumonia by the disc well diffusion method. While anti fungal was determined against two
different strains Candida albicans and Candida glabrata by the agar well diffusion method. In vitro antimicrobial studies revealed that most of the
synthesized compounds showed significant activities as compared to standard drugs chloramphenicol and fluconazole respectively.