DESIGN OF A NOVEL COLON TARGETED MICROSPONGES LOADED WITH DICLOFENAC SODIUM USING THREE DIFFERENT POLYMERS

Abstract

The present investigation was done based on the many frequencies of drug taken orally per single day so, for altering the dose frequency of the drug delivery for the colonic diseases diclofenac sodium was loaded with the microsponges. The colonic targeted microsponges are prepared by acid resistant polymers such as eudragit L100, eudragit RS 100, eudragit EPO 100. These acid resistant polymers release the drug for controlled manner and site specific action. Diclofenac sodium was incorporated into microsponges which help in controlled release of the diclofenac sodium. The polymer used for the preparation of microsponges was useful in forming sponges in which drug was entrapped. FT-IR studies were performed and from the FT-IR spectra it was evident that there were no interactions between the diclofenac sodium and polymer. Formulations of microsponges were prepared by quasi-emulsion solvent diffusion technique using eudragit L100, eudragit RS 100 and eudragit EPO 100 in various ratios such as (1:0.5, 1:1, 1:2 and 1:2). By using the 3 polymers 12 formulations were prepared from the 12 formulations 3 formulations were selected as optimized formulations based on the production yield(%),drug loading(%), encapsulating efficiency and in vitro drug release studies (90.4.7%). Hence, it was proposed that diclofenac sodium microsponges having porous structure and drug release is controlled by predetermined rate. By comparing these three formulations (L2, S3, EPO1) L2 formulation containing EL100 gives the best results.