ANTIUROLITHIATIC EFFECT OF SOME POLYHERBAL FORMULATIONS USED IN EXPERIMENTALLY INDUCED UROLITHIASIS: A REVIEW

Abstract

Urolithiasis is a common problem afflicted for many centuries with high recurrence. The aim of this review is to provide comprehensive information
about six polyherbal formulations used in treatment of urolithiasis. Traditionally, antiurolithiatic plants and combination of plants have been reported
for their scientifically proved pharmacological activities like diuretic, litholytic, antiurolithiatic, antioxidant, astringent, demulcent, lithotriptic,
antispasmodic, analgesic, anti-inflammatory, ACE inhibition and Phospholipase A2 inhibition as a mechanism of action. Mostly for treatment of renal
calculi diuretics or surgical procedure is used. Cystone (750mg/kg) appears to be safe and beneficial in patients who have renal stone. It showed an
increase in expulsion rate of calculi. Antiurolithiatic effect of Rilith (500mg/kg) has determined on ethylene glycol induced lithiasis in male albino
rats also showed prophylactic and curative regimen. Polyherbal I, Polyherbal II and Neeri-KFT also proved to have antiurolithiatic effects.