SYNTHESIS OF NOVEL BENZOPYRONE SUBSTITUTED BENZIMIDAZOLE ANALOGUES AS ANTIBACTERIAL AGENTS

Abstract

A large variety of scientific reviews and reports are providing informations about the effectiveness of synthetic and semi synthetic analogues of benzimidazoles and benzopyrones. It was our interest to explore the novel compounds containing these two fundamental heterocycles in one structure. The present study deals with the synthesis and determination of antibacterial activity of benzopyrone substituted benzimidazole derivatives. The derivatives were synthesized in a good to moderate yields. The structural analysis for the synthesized derivatives was done by IR, ¹HNMR and Mass spectral analysis. Further the compounds were subjected for antibacterial evaluation, among them 5a, 5b, 5g and 5h showed appreciable activity against the strains used. In view of the antibacterial studies, these derivatives can be further modified and investigated for future development.