PREFORMULATION STUDIES OF STAVUDINE FOR TARGETED DRUG DELIVERY SYSTEM

Abstract

The aim of the present study was the pre-formulation parameters of Stavudine for targeted drug delivery system. Data generated from the pre-formulation study may be helpful to initiate the formulation development. The aim of the utilization of pre-formulation data is to maximize the possibilities in formulation for an appropriate, safe, efficacious and stable product and at the equivalent time offer the idea for optimization of the product quality. Stavudine is the nucleoside reverse transcriptase inhibitor used for the acquired immune deficiency syndrome with its oral bioavailability over 80%. The pre-formulation studies were conceded out on physiochemical property for the determination of physical appearance, melting point, solubility profile, partition coefficient and ultra-visible spectrophotometer, infrared spectroscopy, differential scanning calorimetry, determination of quantitative estimation of drug. All the physiochemical data and results showed that the Stavudine could serve as an appropriate candidate drug for targeted drug delivery system.