FORMULATION AND IN-VITRO EVALUATION OF FENOFIBRATE DRY EMULSION IN HARD VEGETARIAN CAPSULES

Abstract

The dry emulsion formulation aims to improve the solubility and dissolution of Fenofibrate. Dry emulsions are an attractive choice because their
physical and micro biological stability. They represent a potential oral drug delivery system for lipophilic and low soluble drug substances. Dry
emulsions can be prepared by spray drying, lyophilization or rotary evaporation. Dry emulsion prepared here was by lyophilization using flaxseed oil
as the lipid phase and HPMC as the carrier. Fenofibrate was the drug of choice as it helps reduce cholesterol and triglycerides (fatty acids) in the
blood. Flaxseed oil has been studied for lowering triglycerides. Hence the combination therapy of Fenofibrate and Flaxseed oil in low doses is
expected to have a synergistic activity in lowering the cholesterol and triglycerides in the blood. The dry emulsion formed has been incorporated in
HPMC (Hydroxyl Propyl Methyl Cellulose) capsules, which provides a vegetarian environment and is a good alternative to gelatin. The formed dry
emulsion formulation has been evaluated for the respective parameters in comparison with the marketed variant and the results are obtained.