FORMULATION AND EVALUATION OF RANITIDINE LOADED CHITOSAN MICROSPHERES

Abstract

The present study aimed at the formulation of Ranitidine hydrochloride loaded chitosan microspheres to prolong the release rate so as to decrease the necessity of multiple dosage and to increase bioavailability. Ranitidine loaded chitosan microspheres were prepared using coacervation-phase separation technique and characterized for the effective delivery of ranitidine. The biodegradable property and good mucoadhesive nature of chitosan on ranitidine drug release was studied. The formulation RCP3 showed rapid drug release after 4 h due to the result of polymer erosion in the surface of microspheres. The prepared microspheres were evaluated for percentage drug loading, entrapment efficiency, and In vitro release characteristics to identify the effect of addition of these polymers. The formulation variables influenced the drug release profile. The results of in vitro release study fitted with kinetic equations indicated that ranitidine drug release followed Higuchi’s matrix model.