SOLUBILITY IMPROVEMENT USING SOLID DISPERSION; STRATEGY, MECHANISM AND CHARACTERIZATION: RESPONSIVENESS AND PROSPECT WAY OUTS

Authors

  • Dinesh Kumar1 Sharma
  • Vipin Bihari2 Gupta
  • Suresh1 Purohit

Keywords:

Solubility enhancement, dissolution enhancement, carriers, mechanisms, characterization

Abstract

New chemicals entities, being synthesized by various techniques, successfully present superior pharmacological activities. However 35-40 % of these new chemicals entities suffer from poor aqueous solubility. The current review extensively highlights various approaches used to enhance solubility, mechanisms responsible for improvement of solubility and characterization. This review also presents attentiveness amongst investigators working on this area and proposes assured promising way outs to improve solubility to obtain stable and effective final products

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Published

17-01-2011

Issue

Volume 2, Issue 1 January 2011

Section

Articles