A PROSPECTIVE STUDY OF ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY AND ITS MANAGEMENT IN A TERTIARY CARE HOSPITAL

Abstract

Tuberculosis (TB) is a very common form of droplet infection. If untreated, the disease may be fatal within 5 years in more than half of cases. To study the frequency of anti-tuberculosis therapy (ATT) induced hepatotoxicity was the subject of the present hospital based descriptive study. A higher risk of hepatotoxicity has been reported in Indian patients ^{3, 5} than in their Western counterparts. This prospective study was conducted in the medicine ward of a tertiary care hospital. Patients admitted in the medicine ward with active pulmonary or extra pulmonary TB, who is taking anti-TB drugs regimen were included. Patients were monitored for liver diseases during the hospital and find out the seriousness and management of hepatotoxicity. 91 patients were included in the study. Of the 91 patients, 20 had developed hepatotoxicity. Therefore, the incidence of ADR amounts to be 21.97%. The mean age of patient who has hepatotoxicity is

34.95. Percentage of ADR was more common in patients aged between 21-30 years. The incidences of hepatotoxicity in females and males were 12.8 % and 9.8% respectively. While assessing seriousness, in most of the patients prolongation of hospitalization occurs and in majority of cases management is done by discontinuing the medication. From the study it is concluded that incidence of ADR is higher and females are more prone to get affected with hepatotoxicity. Continues monitoring is needed for the patients with ATT for identifying the hepatotoxicity. Early detection and proper management is needed.