PROTECTIVE EFFECT OF ROOT EXTRACT OF NOTHOSAERVA BRACHIATA WIGHT IN ETHYLENE GLYCOL INDUCED UROLITHIATIC RATS

Abstract

In India, Berginia ligulata, Family Saxifragaceae is accepted source of ayurvedic drug Pashanabheda. Another species belong to Pashanabheda class is Nothosaerva brachiata Wight. The effect of oral administration of aqueous and alcoholic extract of N. brachiata root on calcium oxalate urolithiasis has been studied in Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and oxalate. Supplementation with aqueous and alcoholic extract of N. brachiata root significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was also significantly lowered by curative treatment using aqueous and alcoholic extracts. The results indicate that the root of Nothosaerva brachiata is endowed with antiurolithiatic activity.