LITHOTRIPTIC EFFECT OF COMBINATION OF MATSYAKSHI (ALTERNANTHERA SESSILIS Linn. R.Br.,) AND TENDER COCONUT WATER IN ALBINO RATS

Abstract

Conversion of the traditional medicinal information into knowledge and its validation through scientific procedures is the need of the day. In the text
Yogamrutha [Traditional Ayurvedic text in Kerala]; it is indicated that the kalka [paste] of Matsyakshi (Alternanthera sessilis Linn. R Br.) in
narikelodakam (tender coconut water) has lithotriptic property. The present study evaluated the In vivo lithotriptic effect of Matsyakshi (Alternanthera
sessilis Linn. R Br.) along with tender coconut water (Cocos nucifera Linn.) in ethylene glycol induced urolithiasis. For inducing calculi, 0.75 %( v/v)
ethylene glycol was given along with drinking water for all groups except the normal control group (Group I) for 28 days. Then the treatment phase
started and continued for next 28 days. The vehicle control group (Group II) received tender coconut water (0.86 ml/200g rat). The standard drug
group (Group III) was treated with cystone (13.5mg/200g rat). Groups IV, V and VI received test drug (0.054g/100g, 0.108g/100g, and 0.216g/100g
kalka respectively) along with tender coconut water. Parameters like serum calcium, serum uric acid serum creatinine, urine creatinine, urine uric acid
and urine calcium were used to assess the activity. Animals treated with the test drug (Group IV, Group V and Group VI) showed highly significant
reduction in all the six parameters. This suggests the ability of the test drug to reduce the biochemical changes induced by ethylene glycol and the
lithotriptic effect of the drug.