DESIGN DEVELOPMENT AND EVALUATION OF MODIFIED RELEASE TABLET OF MONTELUKAST SODIUM USING ETHYL CELLULOSE AND TRAGACANTH
Keywords:
FBD, Montelukast sodium, Ethyl Cellulose, Introduction:Abstract
The purpose of this research was to prepare a modified release tablet of montelukast sodium. Montelukast sodium is Leukotriene antagonist which is rapidly absorbed after the oral administration. The drug was mixed with Ethyl Cellulose and Tragacanth as a dry binder and ethanol was used as solvent to perform the granulation in FBD by the bottom spray method. The granules obtain were mixed with the other ingredients and were compressed using 10 station tablet rotary press. The dissolution was carried out using USP paddle apparatus.
