CHEMICAL COMPOUNDS AND PHARMACOLOGICAL ACTIVITY OF Morus nigra AS A POTENTIAL PRODUCT OF DRUG: A REVIEW

Abstract

Black mulberry fruit (Morus nigra L.) is spread over the subtropical regions of the earth and can grow in various topography and climatic conditions. Its fruit mostly proceeds to become juice, jam, coloring agent and a flavoring for ice cream. Traditionally, the leaves and fruit of Morus nigra L. are used to treat dysentery, diabetes mellitus, hypertension, arthritis, and anemia and can also act as a laxative, odontalgia, anthelmintic, expectorant, hypoglycemic and emetic agent. These pharmacological activities might be caused by a high amount of active compounds in black mulberry. Based on the literature studies, there are 56 compounds isolated from various parts of black mulberry, including the root bark, roots, bark, wood, leaves and fruit. The chemical constituents found in black mulberry contribute to its pharmacological properties, such as antihyperglycemic, cytotoxic against leukemia cells, antioxidative, antibacterial, anti-inflammatory and inhibition of tyrosinase.