PROTECTIVE EFFECT OF SALIX TETRASPERMA ROXBURGH LEAF EXTRACTS AGAINST CARBON TETRACHLORIDE INDUCED LIVER INJURY IN RATS

Abstract

The present study was undertaken to investigate the protective effect of ethanolic and aqueous leaf extracts of Salix tetrasperma Roxburgh against
carbon tetrachloride induced hepatotoxicity in rats. The test extracts administration resulted in significant elevation of biochemical parameters like
viz. serum SGOT, SGPT, ALP, direct bilirubin and total bilirubin levels, while albumin is found to be decreased compared to normal group. Pretreatment with silymarin, ethanolic and aqueous extract of Salix tetrasperma Roxburgh significantly prevented and biochemical changes induced by
these hepatotoxins. Histopathology of liver confirmed our finding as the treatment with the extracts resulted in minor liver cell damage compared to
toxic control group. Our result clearly indicates hepatoprotective effect offered by STEtOH (400 mg/kg, p.o.) was found to be significantly greater
than STAQ (400 mg/kg, p.o.) and standard (silymarin 50 mg/kg, p.o.) group.