FORMULATION AND EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF METOPROLOL

Abstract

Formulated Metoprolol sustained release microspheres. Microspheres are prepared by Ionic-Gelation method using Hydroxy Propyl Methyl Cellulose
(HPMC), Ethyl cellulose and Sodium CMC for sustained release in view to prolong drug release. Metoprolol is an adreno receptor beta blocking
agent used in the treatment of hypertension and characterized by high solubility and high permeability which corresponds to BCS class I drug. Plasma
half life ranges from 3 to 7 hours & oral bioavailability is 50% hence require frequent oral administration for adequate treatment of hypertension.
Administration of conventional tablet of Metoprolol has been reported to exhibit fluctuations in plasma drug levels resulting in either manifestation
side effects reduction in drug concentration at receptor site. so that oral sustained dosage form was developed. The microspheres were evaluated for
various characteristics like encapsulation efficiency, percentage yield, partial size and the In vitro release for 12 hours. The Microspheres were found
to be discrete, spherical, and free-flowing. The microspheres were uniform in size, and the microencapsulation efficiency was in the range of 91.7%.
Microspheres had good spherical geometry